Marks key milestone as Evommune’s first clinical program which should allow EVO101 to rapidly advance into Phase 2a.
Evommune, Inc., a clinical-stage biotechnology company dedicated to the development of transformative medicines for inflammatory diseases, today announced enrollment of the first participant in its Phase 1 study of EVO101 in healthy volunteers. EVO101 is a novel small molecule inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) which broadly inhibits innate inflammation and is being developed as a treatment for inflammatory skin diseases.
“We are excited to enroll the first participant into a clinical study of EVO101, the first of several programs in our pipeline approaching clinical development,” said Eugene A. Bauer, M.D., chief medical officer of Evommune. “Given EVO101’s potent inhibitory activity, this compound has the potential to be a first-in-class treatment with significant efficacy across a broad spectrum of patients. Based on the results of this study, we expect to rapidly advance EVO101 into Phase 2a clinical trials in patients suffering from atopic dermatitis and rosacea.”
The open-label Phase 1 study will assess the safety and tolerability of EVO101 in healthy adult volunteers. Participants will apply EVO101 topical cream, 0.1% twice daily and be evaluated for adverse events and local skin responses over a 7-day period.