MLS-101 is a Highly Selective Aldosterone Synthase Inhibitor Designed to Address  Abnormally Elevated Aldosterone, an Underlying Cause of Hypertension Prevalent in a Significant Portion of Patients

Derek DiRocco of RA Capital Management and Olivier Litzka, PhD of Andera Partners Join Mineralys Board of Directors

Andera Partners, a leading European private equity player, announced today that, together with RA Capital Management, it is leading an oversubscribed and up-sized $118 million Series B financing for Mineralys Therapeutics, Inc., a private, clinical-stage biopharmaceutical company committed to developing a best-in-class, novel therapy for the treatment of hypertension.

Mineralys plans to use the proceeds to continue to advance MLS-101, a highly selective aldosterone synthase inhibitor. MLS-101 is currently being evaluated in a Phase 2 clinical trial, called Target-HTN, for patients with uncontrolled hypertension. The Company anticipates releasing the top-line results of Target-HTN later this year.

Andera participated in the round through its biotech and medtech practice Andera Life Sciences. Additional new investors include RTW Investments, Rock Springs Capital, SR One Capital Management, Sectoral Asset Management and Ysios Capital. Existing investors, including founding investment firm Catalys Pacific, Samsara BioCapital, HBM Healthcare Investments and Adams Street Partners also participated. As part of the Series B financing, Derek DiRocco, Partner, RA Capital Management and Olivier Litzka, PhD, Partner, Andrea Partners will join the Mineralys Board of Directors.

MLS-101 has the potential to be a paradigm-shifting treatment by normalizing plasma aldosterone levels, selectively, without the untoward effects of blocking the mineralocorticoid receptor. This financing will allow us to further our clinical program to unlock the value of MLS-101.” said Jon Congleton, Chief Executive Officer, Mineralys. “We are pleased to be joined by a strong, international group of investors who share our vision of creating a targeted approach to address the growing epidemic of abnormal aldosterone overproduction, that is linked to uncontrolled hypertension and related cardiorenal disorders.”

We are excited to have co-led this financing with Andera Partners and look forward to helping Mineralys progress on the promise of MLS-101 for the treatment of hypertension,” said Derek DiRocco, Partner, RA Capital Management. “RA Capital shares Mineralys’ commitment and belief in the need to bring important new treatments to address the burden and impact of hypertension.”

Hypertension remains the leading cause of heart and kidney disease, but little innovation has been made for over a decade. The work being done by Mineralys addresses an unmet need as more than half of the current patients have uncontrolled blood pressure,” said Olivier Litzka, PhD, Partner, Andrea Partners. “We are pleased to support Mineralys’ experienced team as they work to bring a targeted treatment for the millions of hypertension patients failing to achieve their goal blood pressure.”

We are delighted to have both Olivier and Derek join as new members of the Mineralys Board of Directors,” said BT Slingsby MD, PhD, MPH, Founder & Executive Chairman of Mineralys. “Mineralys was created to transform the diagnosis and treatment of hypertension by targeting one its underlying causes, aldosterone, impacting millions of patients. We look forward to working with our new investors and Board members to advance the MLS-101 development program.”

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ANDERA PARTNERS attire votre attention sur les tentatives de fraudes avec usurpation d’identité qui sévissent actuellement. Les techniques de phishing (ou hameçonnage) évoluent en permanence et sont de plus en plus sophistiquées.

Ces pratiques frauduleuses qui touchent ANDERA PARTNERS, invitent les particuliers à investir dans des comptes à terme et autres produits d’épargne fictifs sous l’identité d’ ANDERA PARTNERS (Andera Co-Invest notamment), et celles de ses collaborateurs et membres des organes de direction, via une adresse fictive et des appels téléphoniques.

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Les fraudeurs ne manquent pas d'imagination pour piéger leurs victimes. Leurs actions visent à récupérer à leur insu et de manière indue des données financières, en incitant leurs victimes à réaliser des transactions dématérialisées.
En cas de doute, pour vous protéger et protéger ANDERA PARTNERS, nous vous invitons à :

*   Vous méfier des demandes inattendues, même si elles semblent provenir de dirigeants ou membre d’organes de direction d’ANDERA PARTNERS ;

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*   Signaler tout message suspect qui vous demande une action immédiate.

La priorité d'ANDERA PARTNERS est de protéger ses clients et ses activités contre la fraude.
Si vous êtes victime d'une tentative d’escroquerie, veuillez contacter les relations investisseurs à l’adresse suivante : ri@anderapartners.com

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LISTE NOIRE DES SOCIÉTÉS FRAUDULEUSES ÉTABLIE PAR L’AMF (AUTORITÉ DES MARCHÉS FINANCIERS) : https://www.amf-france.org/fr/espace-epargnants/proteger-son-epargne/listes-noires-et-mises-en-garde

VICTIME D'UNE ARNAQUE : COMMENT DÉPOSER UNE PLAINTE ? | AMF (AMF-FRANCE.ORG) : https://www.amf-france.org/fr/espace-epargnants/savoir-bien-investir/conseils-pratiques/en-cas-de-problemes/victime-dune-arnaque

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These fraudulent practices, which affect ANDERA PARTNERS, invite individuals to invest in term accounts and other fictitious savings products under the identity of ANDERA PARTNERS (Andera Co-Invest in particular), and those of its employees and members of the management company, via a fictitious address and telephone calls.

Please be extremely vigilant if you receive this type of solicitation. ANDERA PARTNERS does not offer term accounts and does not canvass the public by telephone or e-mail.

Fraudsters do not lack imagination to trap their victims. Their actions are aimed at unknowingly and improperly recovering financial data, by encouraging their victims to carry out dematerialised transactions.
If in doubt, to protect yourself and ANDERA PARTNERS, we invite you to :

* Be wary of unexpected requests, even if they appear to come from ANDERA PARTNERS managers or members of management bodies;

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* Report any suspicious message that asks you to take immediate action.

ANDERA PARTNERS' priority is to protect its customers and its business against fraud.
If you are the victim of a fraud attempt, please contact Investor Relations at the following address: ri@anderapartners.com

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