{"id":7218,"date":"2021-01-07T12:02:00","date_gmt":"2021-01-07T11:02:00","guid":{"rendered":"https:\/\/www.anderapartners.com\/?p=7218"},"modified":"2021-01-07T14:37:12","modified_gmt":"2021-01-07T13:37:12","slug":"am-pharma-announces-enrollment-and-financing-of-covid-19-cohort-in-phase-iii-revival-trial","status":"publish","type":"post","link":"https:\/\/www.anderapartners.com\/en\/am-pharma-announces-enrollment-and-financing-of-covid-19-cohort-in-phase-iii-revival-trial\/","title":{"rendered":"AM-Pharma Announces Enrollment and Financing of COVID-19 Cohort in Phase III REVIVAL Trial"},"content":{"rendered":"

\"\"<\/p>\n

 <\/p>\n

AM-Pharma Announces Enrollment and Financing of COVID-19 Cohort in Phase III REVIVAL Trial<\/strong><\/p>\n

– First patients with COVID-19 enrolled in the REVIVAL Phase III study<\/p>\n

– COVID-19 patients with sepsis-associated acute kidney injury will be included in an exploratory cohort in the pivotal trial enrolling up to 1,600 SA-AKI patients overall<\/p>\n

– RVO, an agency of the Dutch Ministry of Economic Affairs and Climate Policy, provides a loan of up to \u20ac5 million for the COVID-19 cohort clinical study<\/p>\n

AM-Pharma B.V., an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced that the first patients with COVID-19 infection and sepsis-associated acute kidney injury (SA-AKI) have been enrolled in the Company\u2019s Phase III REVIVAL pivotal trial in an exploratory cohort to assess the safety, tolerability and clinical benefit of recombinant alkaline phosphatase.<\/p>\n

Patients with severe COVID-19 infection often present with acute severe inflammation and organ failure. Recent studies conducted in the US demonstrated that up to 90% of the COVID-19 patients that received mechanical ventilation also suffered from AKI and that the development of AKI in these patients is associated with poor prognosis AM-Pharma received an innovation credit of up to EUR 5 million from the \u201cNetherlands Enterprise Agency\u201d (RVO.nl), which has been established by the Dutch Ministry of Economic Affairs and Climate Policy to support the development of innovative programs with promising market potential.<\/p>\n

\u201cThe ongoing coronavirus pandemic and the lack of treatment options for severe cases has been devastating for patients, their families and medical communities around the world,\u201d commented Erik van den Berg<\/a>, Chief Executive Officer at AM-Pharma.<\/strong> \u201cThe prevalence of COVID-19 infections and the high AKI comorbidity support our decision to include this additional cohort into our Phase III REVIVAL pivotal study. By providing our proprietary recombinant alkaline phosphatase to clinicians for evaluation in severe COVID-19 cases, we aim to make our novel treatment option available for these patients.\u201d<\/p>\n

The REVIVAL Phase III pivotal trial is a randomized, double-blind, placebo-controlled, two-arm, parallel-group, multi-center trial to evaluate the efficacy and safety of AM-Pharma\u2019s proprietary human recombinant alkaline phosphatase for the treatment of patients with SA-AKI. The study will enroll approximately 1400 patients with SA-AKI in the main study population. In two exploratory cohorts, up to 100 patients with moderate Chronic Kidney Disease (CKD) and up to 100 patients with COVID-19 will be enrolled. The primary aim of the study is to confirm the improvement on the primary endpoint of 28-day all-cause mortality, as observed in the Phase II STOP-AKI study. Secondary endpoints include the treatment effect on long-term Major Adverse Kidney Events (MAKE), on the use of organ support, length of stay in the ICU and on 90-day all cause mortality. Further information on this study can be found at www.clinicaltrials.gov<\/a>, NCT04411472 (REVIVAL)<\/a>.<\/p>\n

\u201cWe have seen the potential of AM-Pharma\u2019s proprietary recombinant human alkaline phosphatase to benefit patients with sepsis and acute kidney injury, as demonstrated in the Phase II STOP-AKI study,\u201d said John A. Kellum, M.D., Professor, Vice Chair Department of Critical Care Medicine and Director at the Center for Critical Care Nephrology at University of Pittsburgh.<\/strong> \u201cThis is very relevant for severe COVID-19 patients as many of these patients also experience AKI, with increased AKI severity being correlated with increased mortality.\u201d<\/p>\n

Professor Peter Pickkers, M.D., Ph.D., Chair of Experimental Intensive Care Medicine, Radboud\u00a0 University Medical Center, and principal investigator of the REVIVAL study<\/strong> added: \u201cThe relative reduction in mortality of 40% and significant improvement in renal function over the course of the Phase II STOP-AKI study period support the hypothesis that AM-Pharma\u2019s drug candidate might provide a unique treatment opportunity for severe COVID-19 patients with acute kidney injury. I am excited to continue our collaboration with AM-Pharma for this trial.\u201d<\/p>\n

For the Phase III REVIVAL trial, potentially over 100 sites across Europe and North America are actively recruiting patients with SA-AKI in the trial. Enrollment completion of the first 400 patients in the main study population is expected by the end of 2021. The company expects to complete target enrollment and to announce data on the primary endpoint of 28-day all-cause mortality in 2023.<\/p>\n

To read AM-Pharmas\u2019 press release, please click here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

  AM-Pharma Announces Enrollment and Financing of COVID-19 Cohort in Phase III REVIVAL Trial – First patients with COVID-19 enrolled in the REVIVAL Phase III study – COVID-19 patients with sepsis-associated acute kidney injury will be included in an exploratory cohort in the pivotal trial enrolling up to 1,600 SA-AKI patients overall – RVO, an…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[123],"class_list":["post-7218","post","type-post","status-publish","format-standard","hentry","category-biodiscovery-en"],"acf":[],"yoast_head":"\nAM-Pharma Announces Enrollment and Financing of COVID-19 Cohort in Phase III REVIVAL Trial - ANDERA PARTNERS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.anderapartners.com\/fr\/am-pharma-announces-enrollment-and-financing-of-covid-19-cohort-in-phase-iii-revival-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AM-Pharma Announces Enrollment and Financing of COVID-19 Cohort in Phase III REVIVAL Trial - 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